Masao Kaneki Selected Research

Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)

1/2018	iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice.
1/2017	iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53.
1/2015	Voluntary Exercise Can Ameliorate Insulin Resistance by Reducing iNOS-Mediated S-Nitrosylation of Akt in the Liver in Obese Rats.
11/2014	Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
3/2013	iNOS inhibitor, L-NIL, reverses burn-induced glycogen synthase kinase-3β activation in skeletal muscle of rats.
1/2012	Inducible nitric oxide synthase deficiency ameliorates skeletal muscle insulin resistance but does not alter unexpected lower blood glucose levels after burn injury in C57BL/6 mice.
10/2011	Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice.
8/2011	Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.
3/2007	Nitrosative stress and pathogenesis of insulin resistance.
5/2005	A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.

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Masao Kaneki Research Topics

Disease

19	Insulin Resistance 01/2019 - 02/2002
18	Burns 01/2019 - 03/2005
16	Inflammation (Inflammations) 01/2021 - 04/2005
9	Sepsis (Septicemia) 01/2021 - 01/2010
6	Obesity 01/2015 - 04/2005
6	Hyperglycemia 12/2013 - 02/2002
5	Muscular Atrophy (Muscle Atrophy) 01/2021 - 05/2013
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 10/2016
4	Critical Illness (Critically Ill) 12/2017 - 03/2005
4	Atherosclerosis 02/2008 - 04/2005
4	Osteoporosis 02/2008 - 04/2005
3	Body Weight (Weight, Body) 02/2018 - 12/2011
3	Ischemia 11/2015 - 08/2007
3	Septic Shock (Toxic Shock Syndrome) 09/2015 - 01/2007
3	Parkinson Disease (Parkinson's Disease) 11/2014 - 11/2010
3	Vitamin K Deficiency 02/2008 - 07/2006
2	Paraplegia (Spastic Paraplegia) 01/2019 - 08/2011
2	Spinal Cord Ischemia 01/2019 - 08/2011
2	Hyperlactatemia 01/2019 - 01/2017
2	Hypoxia (Hypoxemia) 10/2017 - 01/2017
2	Hypertrophy 10/2015 - 03/2005
2	Atrophy 01/2014 - 03/2005
2	Muscular Dystrophies (Muscular Dystrophy) 05/2013 - 08/2007
2	Type 2 Diabetes Mellitus (MODY) 08/2011 - 03/2007
2	Gliosis 08/2011 - 07/2011
2	Endotoxemia 01/2010 - 01/2007
2	Hepatocellular Carcinoma (Hepatoma) 09/2006 - 07/2006
1	Liver Diseases (Liver Disease) 01/2021
1	Cachexia 01/2021
1	Rupture 01/2021
1	Tuberous Sclerosis (Bourneville's Disease) 01/2021
1	Acute Kidney Injury (Acute Renal Failure) 01/2021
1	Lipodystrophy 02/2018
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2018

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2002
14	Insulin (Novolin)FDA Link 01/2019 - 02/2002
13	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2018 - 02/2002
9	Farnesyltranstransferase (Farnesyltransferase)IBA 01/2021 - 06/2007
9	Glucose (Dextrose)FDA LinkGeneric 10/2017 - 02/2002
7	salicylhydroxamic acid (SHAM)IBA 01/2017 - 05/2006
5	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2013 - 01/2010
5	Caspase 3 (Caspase-3)IBA 06/2013 - 11/2010
5	Vitamin K FDA Link 09/2009 - 04/2005
4	CytokinesIBA 01/2021 - 08/2012
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2015 - 08/2010
4	Simvastatin (Zocor)FDA LinkGeneric 05/2015 - 09/2010
4	Insulin Receptor Substrate ProteinsIBA 01/2012 - 10/2004
3	FTI 277IBA 01/2021 - 12/2011
3	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2019 - 07/2011
3	tipifarnib (R115777)IBA 02/2018 - 12/2014
3	Cholinergic ReceptorsIBA 01/2017 - 01/2014
3	3-(2,4-dimethoxybenzylidene)anabaseineIBA 01/2017 - 08/2012
3	LipidsIBA 01/2015 - 01/2010
3	Insulin ReceptorIBA 08/2010 - 10/2004
3	Hemostatics (Antihemorrhagics)IBA 02/2008 - 07/2006
3	Biological ProductsIBA 09/2006 - 05/2006
2	coenzyme Q10 (CoQ10)IBA 01/2019 - 10/2013
2	CholesterolIBA 02/2018 - 12/2011
2	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2017 - 01/2007
2	Interleukin-6 (Interleukin 6)IBA 01/2017 - 03/2011
2	Sirtuin 1IBA 01/2017 - 11/2014
2	Oxygen (Dioxygen)IBA 11/2015 - 10/2013
2	Protein SIBA 10/2015 - 04/2013
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2015 - 06/2013
2	Cysteine (L-Cysteine)FDA Link 01/2015 - 12/2014
2	Nitric Oxide Synthase (NO Synthase)IBA 04/2013 - 01/2007
2	Glycogen Synthase (Synthase I)IBA 03/2013 - 10/2011
2	Blood Glucose (Blood Sugar)IBA 01/2012 - 09/2009
2	AntioxidantsIBA 12/2011 - 07/2011
2	Glycogen Phosphorylase (Phosphorylase, Glycogen)IBA 10/2011 - 02/2002
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 07/2011 - 11/2010
2	NeurotoxinsIBA 07/2011 - 06/2007
2	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 07/2011 - 11/2010
2	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 09/2010 - 12/2008
2	Apolipoproteins E (ApoE)IBA 02/2008 - 06/2007
2	Vitamin K 1 (Phylloquinone)FDA LinkGeneric 02/2008 - 09/2006
2	EndotoxinsIBA 01/2007 - 02/2002
2	Vitamin K 2 (Vitamin K2)IBA 09/2006 - 04/2005
2	Glutamic Acid (Glutamate)FDA Link 09/2006 - 07/2006
2	VitaminsIBA 09/2006 - 07/2006
2	EnzymesIBA 05/2006 - 02/2002
1	Alanine Transaminase (SGPT)IBA 01/2021
1	Mitochondrial DNA (mtDNA)IBA 01/2021
1	Tuberous Sclerosis Complex 2 ProteinIBA 01/2021
1	Tuberous Sclerosis Complex 1 ProteinIBA 01/2021
1	Lipocalin-2IBA 01/2021
1	MyostatinIBA 01/2021
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2021
1	Peroxidase (Myeloperoxidase)IBA 01/2021
1	HMGB1 Protein (HMG1)IBA 01/2021
1	trans-sodium crocetinate (crocetin)IBA 01/2021
1	SestrinsIBA 01/2020
1	lonafarnib (SCH 66336)IBA 02/2018
1	HIV Protease InhibitorsIBA 02/2018
1	Ritonavir (Norvir)FDA Link 02/2018
1	LeptinIBA 02/2018

Therapy/Procedure

4	Anesthesia 01/2015 - 03/2011
3	Therapeutics 10/2009 - 08/2007
2	Ligation 12/2011 - 03/2011
2	Punctures 12/2011 - 03/2011